Police found the 35-year-old victim at 1.22am today after being called to a fast food restaurant in Barking Road.
Paramedics rushed him to a hospital, where he is in a serious but stable condition.
Officers have arrested two women, aged 32 and 36-years-old, on suspicion of grievous bodily harm.
A cordon has been set up in Beckton Road where it is believed events leading up to the attack began.